SNCA Protein (full length)
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- Antigène Voir toutes SNCA Protéines
- SNCA (Synuclein, alpha (SNCA))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- full length
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Application
- SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
- Séquence
- MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- Specificité
- ~14.46 kDa
- Purification
- Ion-exchange Purified
- Pureté
- 92% pure using SDSPAGE analysis.
- Biological Activity Comment
- Thioflavin T curve shows less β-sheet aggregation when Type 2 monomers (SPR-316) are seeded with PFFs compared to Type 1 monomers (SPR-321) seeded with PFFs.
- Top Product
- Discover our top product SNCA Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Certified 92% pure using SDS-PAGE analysis.
- Restrictions
- For Research Use only
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- Concentration
- Lot specific
- Buffer
- PBS pH 7.4
- Stock
- -80 °C
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- Antigène
- SNCA (Synuclein, alpha (SNCA))
- Autre désignation
- Alpha Synuclein (SNCA Produits)
- Synonymes
- snca Protein, MGC64356 Protein, LOC619283 Protein, NACP Protein, alphaSYN Protein, PARK1 Protein, PARK4 Protein, PD1 Protein, synuclein alpha L homeolog Protein, alpha-synuclein Protein, synuclein alpha Protein, synuclein, alpha Protein, snca.L Protein, LOC619283 Protein, SNCA Protein, Snca Protein
- Sujet
- Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
- ID gène
- 6622
- NCBI Accession
- NP_000336
- UniProt
- P37840
- Pathways
- Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
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