Ret Proto-Oncogene Protein (RET) (DYKDDDDK-His Tag)

N° du produit ABIN5505759

Détail du produit

Antigène: Ret Proto-Oncogene (RET)

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Ret Proto-Oncogene protéine est marqué à la DYKDDDDK-His Tag.

Application: Antibody Production (AbP), Standard (STD)

Attributs du produit:

• Recombinant human Purified recombinant protein of human ret proto-oncogene (RET), with C-terminal DDK/His tag, expressed in human cells, 20 μg (C-term DDK/His tag) protein expressed in Human 293HEK cells.
• Produced with end-sequenced ORF clone

Purification: Purified

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 1 x PBS, pH 7.4, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: Ret Proto-Oncogene (RET)

Autre désignation: ret proto-oncogene (RET Produits)

Synonymes: c-ret Protein, cret Protein, etID315074.13 Protein, ret1 Protein, wu:fd13h01 Protein, X-ret Protein, ret-A Protein, xret Protein, RET Protein, MTC1 Protein, CDHF12 Protein, CDHR16 Protein, HSCR1 Protein, MEN2A Protein, MEN2B Protein, PTC Protein, RET-ELE1 Protein, RET51 Protein, RET9 Protein, c-Ret Protein, ret proto-oncogene receptor tyrosine kinase Protein, ret proto-oncogene S homeolog Protein, ret proto-oncogene Protein, ret Protein, ret.S Protein, RET Protein, Ret Protein

Sujet: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Poids moléculaire: 70.5 kDa

NCBI Accession: NP_066124

Pathways: Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation