SLIT2 Protein (DYKDDDDK Tag)
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- Antigène Voir toutes SLIT2 Protéines
- SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette SLIT2 protéine est marqué à la DYKDDDDK Tag.
- Application
- SDS-PAGE (SDS)
- Réactivité croisée
- Humain
- Attributs du produit
- Human Slit2 (aa 1122-1529) is fused at the C-terminus to a FLAG®-tag.
- Pureté
- >95 % (SDS-PAGE)
- niveau d'endotoxine
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product SLIT2 Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Activates an UCP1-luciferase construct in mouse fat primary cells at a concentration of 20nM.
- Restrictions
- For Research Use only
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- Format
- Solid
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Date de péremption
- 6 months
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- Antigène
- SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))
- Autre désignation
- Slit2 (SLIT2 Produits)
- Synonymes
- SLIL3 Protein, Slit-2 Protein, Drad-1 Protein, E030015M03Rik Protein, E130320P19Rik Protein, Slil3 Protein, mKIAA4141 Protein, Slit Protein, slil3 Protein, slit-2 Protein, slit2-a Protein, SLIT2 Protein, slit guidance ligand 2 Protein, slit homolog 2 (Drosophila) Protein, slit guidance ligand 2 S homeolog Protein, SLIT2 Protein, Slit2 Protein, slit2 Protein, slit2.S Protein
- Sujet
- The Slits are secreted proteins that bind to Robo receptors and play a role in axon guidance and neuronal migration. The Slit family in mice and humans comprises three members: Slit1, Slit2 and Slit3. These are all extracellular matrix proteins of 180-200 kDa. In vivo, Slit2 is cleaved into 140 kDa N-terminal (Slit2-N) and 55-60 kDa C-terminal (Slit2-C) fragments. Only Slit2-N and Slit2 full-length bind the Robo proteins. Recently, it has been shown that Slit2 is highly expressed in adipose tissues under the control of PRDM16 and cold exposure. Slit2 is posttranslationally cleaved by adipocytes and the resulting Slit2-C fragment improves glucose homeostasis in mice by activating a thermogenic PKA/cAMP pathway not mediated by beta-adrenergic receptors in adipocytes.
- Poids moléculaire
- ~55kDa
- UniProt
- O94813
- Pathways
- Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration
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