Neuregulin 4 Protein (NRG4) (partial) (His tag)
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- Antigène Voir toutes Neuregulin 4 (NRG4) Protéines
- Neuregulin 4 (NRG4)
- Type de proteíne
- Recombinant
- Attributs du protein
- partial
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Neuregulin 4 protéine est marqué à la His tag.
- Application
- Western Blotting (WB)
- Séquence
- Pro 2 - Phe 62
- Pureté
- >90 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Endotoxin level is less than 1.0 EU per ug by the LAL method.
- Top Product
- Discover our top product NRG4 Protéine
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- Indications d'application
- This recombinant protein can be used for WB.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM NaCl, pH 7.5
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C.
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- Antigène
- Neuregulin 4 (NRG4)
- Autre désignation
- Neuregulin-4 (NRG4 Produits)
- Synonymes
- HRG4 Protein, AI552600 Protein, neuregulin 4 Protein, NRG4 Protein, Nrg4 Protein, LOC100347220 Protein
- Sujet
- Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival. The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation. Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
- Poids moléculaire
- 8.6 kDa
- ID gène
- 145957
- UniProt
- Q8WWG1
- Pathways
- Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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