CASP14 Protein (AA 153-240) (GST tag)

N° du produit ABIN5709199

Détail du produit

Antigène: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Type de proteíne: Recombinant

Attributs du protein: AA 153-240

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette CASP14 protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS)

Séquence: KDSPQTIPTY TDALHVYSTV EGYIAYRHDQ KGSCFIQTLV DVFTKRKGHI LELLTEVTRR MAEAELVQEG KARKTNPEIQ STLRKRLY

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))

Autre désignation: CASPE (CASP14 Produits)

Synonymes: CASP14 Protein, MICE Protein, mini-ICE Protein, caspase 14, apoptosis-related cysteine peptidase Protein, caspase 14 Protein, caspase-14-like Protein, caspase-14 Protein, CASP14 Protein, Casp14 Protein, LOC485601 Protein, LOC780455 Protein

Sujet: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum . Ses to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin . In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF . Involved in processing of prosaposin in the epidermis . May be involved in retinal pigment epithelium cell barrier function . Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD .

Poids moléculaire: 37.6 kDa

UniProt: P31944