Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.1-2 mg/mL
Buffer
20 mM Tris-HCl based buffer, pH 8.0
Stock
-80 °C,4 °C,-20 °C
Stockage commentaire
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Antigène
KCNJ1
(Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1))
KIR1.1 Protein, ROMK Protein, ROMK1 Protein, kir1.1 Protein, romk1 Protein, Kcnj Protein, Kir1.1 Protein, Romk2 Protein, kcnj1 Protein, wu:fl37c05 Protein, zgc:63534 Protein, potassium voltage-gated channel subfamily J member 1 Protein, potassium voltage-gated channel subfamily J member 1 L homeolog Protein, potassium inwardly-rectifying channel, subfamily J, member 1 Protein, potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1 Protein, KCNJ1 Protein, kcnj1.L Protein, kcnj1 Protein, Kcnj1 Protein, kcnj1a.1 Protein
Sujet
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium.