MUSK Protein (AA 24-495, Extracellular) (GST tag)

N° du produit ABIN5709979

Détail du produit

Antigène: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Type de proteíne: Recombinant

Attributs du protein: Extracellular, AA 24-495

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette MUSK protéine est marqué à la GST tag.

Application: SDS-PAGE (SDS)

Séquence: LPKAPVITTP LETVDALVEE VATFMCAVES YPQPEISWTR NKILIKLFDT RYSIRENGQL LTILSVEDSD DGIYCCTANN GVGGAVESCG ALQVKMKPKI TRPPINVKII EGLKAVLPCT TMGNPKPSVS WIKGDSPLRE NSRIAVLESG SLRIHNVQKE DAGQYRCVAK NSLGTAYSKV VKLEVEEESE PEQDTKVFAR ILRAPESHNV TFGSFVTLHC TATGIPVPTI TWIENGNAVS SGSIQESVKD RVIDSRLQLF ITKPGLYTCI ATNKHGEKFS TAKAAATISI AEWREYCLAV KELFCAKEWL VMEEKTHRGL YRSEMHLLSV PECSKLPSMH WDPTACARLP HLAFPPMTSS KPSVDIPNLP SSSSSSFSVS PTYSMTVIIS IMSSFAIFVL LTITTLYCCR RRKQWKNKKR ESAAVTLTTL PSELLLDRLH PNPMYQRMPL LLNPKLLSLE YPRNNIEYVR DI

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Autre désignation: MUSK (MUSK Produits)

Synonymes: unp Protein, fj98e12 Protein, zgc:63467 Protein, wu:fj98e12 Protein, si:dz46m7.2 Protein, si:dz57f23.3 Protein, si:busm1-57f23.3 Protein, musk-A Protein, MuSK Protein, MUSK Protein, Mdk4 Protein, Mlk Protein, Nsk1 Protein, Nsk2 Protein, Nsk3 Protein, muscle Protein, muscle associated receptor tyrosine kinase Protein, muscle, skeletal, receptor tyrosine kinase Protein, muscle associated receptor tyrosine kinase S homeolog Protein, MUSK Protein, musk Protein, musk.S Protein, Musk Protein

Sujet: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle . Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic mbrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to mbranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous syst by mediating cholinergic responses, synaptic plasticity and mory formation .1 Publication

Poids moléculaire: 79.9 kDa

UniProt: O15146

Pathways: Signalisation RTK, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development