TRIM11 Protein (AA 267-468, partial) (His-SUMO Tag)

N° du produit ABIN5711713

Détail du produit

Antigène: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Type de proteíne: Recombinant

Attributs du protein: AA 267-468, partial

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette TRIM11 protéine est marqué à la His-SUMO Tag.

Application: SDS-PAGE (SDS)

Séquence: MELRTVCRVP GLVETLRRFR GDVTLDPDTA NPELILSEDR RSVQRGDLRQ ALPDSPERFD PGPCVLGQER FTSGRHYWEV EVGDRTSWAL GVCRENVNRK EKGELSAGNG FWILVFLGSY YNSSERALAP LRDPPRRVGI FLDYEAGHLS FYSATDGSLL FIFPEIPFSG TLRPLFSPLS SSPTPMTICR PKGGSGDTLA PQ

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: TRIM11 (Tripartite Motif Containing 11 (TRIM11))

Autre désignation: TRI11 (TRIM11 Produits)

Synonymes: BIA1 Protein, RNF92 Protein, TRIM11 Protein, tripartite motif containing 11 Protein, tripartite motif-containing 11 Protein, TRIM11 Protein, Trim11 Protein

Sujet: E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.

Poids moléculaire: 38.5 kDa

UniProt: Q96F44