C4B Protein (AA 1454-1744) (His tag)

N° du produit ABIN5713996

Détail du produit

Antigène: C4B (C4b) (Complement Component C4b (C4b))

Type de proteíne: Recombinant

Attributs du protein: AA 1454-1744

Origine: Humain

Source: Levure

Purification/Conjugué: Cette C4B protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: EAPKVVEEQE SRVHYTVCIW RNGKVGLSGM AIADVTLLSG FHALRADLEK LTSLSDRYVS HFETEGPHVL LYFDSVPTSR ECVGFEAVQE VPVGLVQPAS ATLYDYYNPE RRCSVFYGAP SKSRLLATLC SAEVCQCAEG KCPRQRRALE RGLQDEDGYR MKFACYYPRV EYGFQVKVLR EDSRAAFRLF ETKITQVLHF TKDVKAAANQ MRNFLVRASC RLRLEPGKEY LIMGLDGATY DLEGHPQYLL DSNSWIEEMP SERLCRSTRQ RAACAQLNDF LQEYGTQGCQ V

Purification: SDS-PAGE

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Stock: -80 °C,4 °C,-20 °C

Stockage commentaire: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Détail du antigène

Antigène: C4B (C4b) (Complement Component C4b (C4b))

Autre désignation: CO4B (C4b Produits)

Synonymes: C4B1 Protein, C4B12 Protein, C4B2 Protein, C4B3 Protein, C4B5 Protein, C4BD Protein, C4B_2 Protein, C4F Protein, CH Protein, CO4 Protein, CPAMD3 Protein, C4 Protein, C4A2 Protein, C4A3 Protein, C4A4 Protein, C4A6 Protein, C4AD Protein, C4S Protein, CPAMD2 Protein, RG Protein, wu:fi14a03 Protein, C4B Protein, DKFZP469I0332 Protein, Slp Protein, Ss Protein, C4-2 Protein, C4l Protein, complement C4B (Chido blood group) Protein, complement C4A (Rodgers blood group) Protein, complement component 4 Protein, complement C4-B Protein, complement component 4B (Chido blood group) Protein, complement component 4A (Rodgers blood group) Protein, C4B Protein, C4A Protein, c4 Protein, LOC462577 Protein, C4a Protein, C4b Protein

Sujet: Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complent pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.Derived from proteolytic degradation of complent C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Poids moléculaire: 35.1 kDa

UniProt: P0C0L5

Pathways: Système du Complément