Norrie Disease (Pseudoglioma) Protein (NDP) (AA 25-133) (His tag)
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- Antigène Voir toutes Norrie Disease (Pseudoglioma) (NDP) Protéines
- Norrie Disease (Pseudoglioma) (NDP)
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 25-133
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette Norrie Disease (Pseudoglioma) protéine est marqué à la His tag.
- Application
- SDS-PAGE (SDS)
- Séquence
- MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS
- Pureté
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product NDP Protéine
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M urea, 10 % glycerol
- Stock
- 4 °C,-20 °C,-80 °C
- Stockage commentaire
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Antigène
- Norrie Disease (Pseudoglioma) (NDP)
- Autre désignation
- NDP (NDP Produits)
- Synonymes
- EVR2 Protein, FEVR Protein, ND Protein, evr2 Protein, fevr Protein, xnorrin Protein, Ndph Protein, RGD1563968 Protein, NDP, norrin cystine knot growth factor Protein, Norrie disease (pseudoglioma) L homeolog Protein, Norrie disease (pseudoglioma) (human) Protein, NDP Protein, ndp.L Protein, Ndp Protein
- Sujet
- Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Poids moléculaire
- 14.8 kDa (132aa)
- NCBI Accession
- NP_000257
- UniProt
- Q00604
- Pathways
- Sensory Perception of Sound
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