HLA-DRA Protein (AA 26-216) (His tag)

N° du produit ABIN5853581

Détail du produit

Antigène: HLA-DRA (HLA Class II DR alpha (HLA-DRA))

Type de proteíne: Recombinant

Attributs du protein: AA 26-216

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette HLA-DRA protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: MGSSHHHHHH SSGLVPRGSH MIKEEHVIIQ AEFYLNPDQS GEFMFDFDGD EIFHVDMAKK ETVWRLEEFG RFASFEAQGA LANIAVDKAN LEIMTKRSNY TPITNVPPEV TVLTNSPVEL REPNVLICFI DKFTPPVVNV TWLRNGKPVT TGVSETVFLP REDHLFRKFH YLPFLPSTED VYDCRVEHWG LDEPLLKHWE FDAPSPLPET TE

Pureté: > 90 % by SDS - PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.15M NaCl, 10 % glycerol, 1  mM DTT

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: HLA-DRA (HLA Class II DR alpha (HLA-DRA))

Autre désignation: HLA-DRA (HLA-DRA Produits)

Synonymes: HLA-DRA1 Protein, MLRW Protein, DR-alpha Protein, HLA-DRA Protein, Mamu-DRA1 Protein, major histocompatibility complex, class II, DR alpha L homeolog Protein, major histocompatibility complex, class II, DR alpha Protein, hla-dra.L Protein, HLA-DRA Protein, MAMU-DRA Protein, BOLA-DRA Protein

Sujet: Major histocompatibility complex, class II, DR alpha, also known as HLA-DRA, binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Recombinant human HLA-DRA, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Poids moléculaire: 24.3 kDa (212aa) confirmed by MALDI-TOF

NCBI Accession: NP_061984

UniProt: P01903

Pathways: TCR Signaling, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response