merit40 Protein, nba1 Protein, zgc:100909 Protein, c19orf62 Protein, C19orf62 Protein, MERIT40 Protein, NBA1 Protein, C7H19orf62 Protein, 5430437P03Rik Protein, Merit40 Protein, BRISC and BRCA1 A complex member 1 Protein, BRISC and BRCA1 A complex member 1 L homeolog Protein, babam1 Protein, BABAM1 Protein, babam1.L Protein, Babam1 Protein
Sujet
BABAM1 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Recombinant human BABAM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.