CRALBP Protein, 3110056M11Rik Protein, rlbp1 Protein, MGC64381 Protein, CRALBPb Protein, zgc:77766 Protein, MGC69448 Protein, RLBP1 Protein, CRALBPa Protein, rlbp1l Protein, zgc:73076 Protein, retinaldehyde binding protein 1 Protein, retinaldehyde binding protein 1 L homeolog Protein, retinaldehyde binding protein 1b Protein, retinaldehyde binding protein 1a Protein, RLBP1 Protein, Rlbp1 Protein, rlbp1.L Protein, rlbp1b Protein, rlbp1 Protein, rlbp1a Protein
Sujet
Igfbp6, also known as insulin-like growth factor-binding protein 6, binds insulin-like growth factor 1(IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. It is a cysteine-rich protein with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. It plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity. Recombinant mouse Igfbp6, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Poids moléculaire
23.7kDa (221aa) 28-40kDa (SDS-PAGE under reducing conditions)