FGFR2 Protein (AA 22-378) (hIgG-His-tag)

N° du produit ABIN5854934

Détail du produit

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Type de proteíne: Recombinant

Attributs du protein: AA 22-378

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette FGFR2 protéine est marqué à la hIgG-His-tag.

Application: SDS-PAGE (SDS)

Séquence: RPSFSLVEDT TLEPEEPPTK YQISQPEVYV AAPGESLEVR CLLKDAAVIS WTKDGVHLGP NNRTVLIGEY LQIKGATPRD SGLYACTASR TVDSETWYFM VNVTDAISSG DDEDDTDGAE DFVSENSNNK RAPYWTNTEK MEKRLHAVPA ANTVKFRCPA GGNPMPTMRW LKNGKEFKQE HRIGGYKVRN QHWSLIMESV VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG GDVEFVCKVY SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT EADAGEYICK VSNYIGQANQ SAWLTVLPKQ QAPGREKEIT ASPDYLELEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH

Pureté: > 95 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Autre désignation: FGFR2 (FGFR2 Produits)

Synonymes: FGFR2 Protein, FGFR2IIIb Protein, bek Protein, bfr-1 Protein, cd332 Protein, cek3 Protein, cfd1 Protein, ect1 Protein, fgfr-2 Protein, jws Protein, k-sam Protein, kgfr Protein, tk14 Protein, tk25 Protein, xfgfr2 Protein, DKFZp469H1521 Protein, BBDS Protein, BEK Protein, BFR-1 Protein, CD332 Protein, CEK3 Protein, CFD1 Protein, ECT1 Protein, JWS Protein, K-SAM Protein, KGFR Protein, TK14 Protein, TK25 Protein, AU043015 Protein, AW556123 Protein, Bek Protein, Fgfr-2 Protein, Fgfr-7 Protein, Fgfr7 Protein, KGFRTr Protein, svs Protein, FGF-R Protein, fgfr72IIIb Protein, FGFR Protein, fc56c05 Protein, wu:fc56c05 Protein, fibroblast growth factor receptor 2 Protein, fibroblast growth factor receptor 2 L homeolog Protein, FGFR2 Protein, LOC100084641 Protein, fgfr2 Protein, Fgfr2 Protein, fgfr2.L Protein

Sujet: FGFR2, also known as fibroblast growth factor receptor 2 isoform 2, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. It plays an important regulatory role in skeletal development and bone formation. Its dysregulation results in a spectrum of bone and skin pathologies and several types of cancer. Recombinant human FGFR2, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 66.6kDa (596aa) 70-100kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_075259

UniProt: P21802

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding