FGFR3 Protein (AA 23-375) (hIgG-His-tag)

N° du produit ABIN5854978

Détail du produit

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Type de proteíne: Recombinant

Attributs du protein: AA 23-375

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette FGFR3 protéine est marqué à la hIgG-His-tag.

Application: SDS-PAGE (SDS)

Séquence: ESLGTEQRVV GRAAEVPGPE PGQQEQLVFG SGDAVELSCP PPGGGPMGPT VWVKDGTGLV PSERVLVGPQ RLQVLNASHE DSGAYSCRQR LTQRVLCHFS VRVTDAPSSG DDEDGEDEAE DTGVDTGAPY WTRPERMDKK LLAVPAANTV RFRCPAAGNP TPSISWLKNG REFRGEHRIG GIKLRHQQWS LVMESVVPSD RGNYTCVVEN KFGSIRQTYT LDVLERSPHR PILQAGLPAN QTAVLGSDVE FHCKVYSDAQ PHIQWLKHVE VNGSKVGPDG TPYVTVLKTA GANTTDKELE VLSLHNVTFE DAGEYTCLAG NSIGFSHHSA WLVVLPAEEE LVEADEAGSV YAGLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH

Pureté: > 95 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))

Autre désignation: FGFR3 (FGFR3 Produits)

Synonymes: FGFR3 Protein, LOC100034114 Protein, ACH Protein, CD333 Protein, CEK2 Protein, HSFGFR3EX Protein, JTK4 Protein, FR3 Protein, Fgfr-3 Protein, Flg-2 Protein, HBGFR Protein, Mfr3 Protein, sam3 Protein, fc27h01 Protein, wu:fc27h01 Protein, fibroblast growth factor receptor 3 Protein, fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) S homeolog Protein, FGFR3 Protein, fgfr3.S Protein, Fgfr3 Protein, fgfr3 Protein

Sujet: FGFR3, also known as fibroblast growth factor receptor 3 isoform 1, is a member of the fibroblast growth factor receptor family. It is a family of polypeptide growth factors involved in a variety of activities including mitogenesis, angiogenesis, and wound healing. Its activation results in autophosphorylation of multiple tyrosine residues within the intracellular domain. It plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. It frequently involved in human developmental disorders and is associated with several cancers, including multiple myeloma (MM). Recombinant human FGFR3, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 65.1kDa (592aa) 70-100kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_000133

UniProt: P22607

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding