KIT Protein (AA 26-524) (His tag)

N° du produit ABIN5854993

Détail du produit

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Type de proteíne: Recombinant

Attributs du protein: AA 26-524

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette KIT protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: QPSVSPGEPS PPSIHPGKSD LIVRVGDEIR LLCTDPGFVK WTFEILDETN ENKQNEWITE KAEATNTGKY TCTNKHGLSN SIYVFVRDPA KLFLVDRSLY GKEDNDTLVR CPLTDPEVTN YSLKGCQGKP LPKDLRFIPD PKAGIMIKSV KRAYHRLCLH CSVDQEGKSV LSEKFILKVR PAFKAVPVVS VSKASYLLRE GEEFTVTCTI KDVSSSVYST WKRENSQTKL QEKYNSWHHG DFNYERQATL TISSARVNDS GVFMCYANNT FGSANVTTTL EVVDKGFINI FPMINTTVFV NDGENVDLIV EYEAFPKPEH QQWIYMNRTF TDKWEDYPKS ENESNIRYVS ELHLTRLKGT EGGTYTFLVS NSDVNAAIAF NVYVNTKPEI LTYDRLVNGM LQCVAAGFPE PTIDWYFCPG TEQRCSASVL PVDVQTLNSS GPPFGKLVVQ SSIDSSAFKH NGTVECKAYN DVGKTSAYFN FAFKGNNKEQ IHPHTLFTPL EHHHHHH

Pureté: > 90 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Autre désignation: KIT (KIT Produits)

Synonymes: C-Kit Protein, CD117 Protein, PBT Protein, SCFR Protein, Bs Protein, Fdc Protein, Gsfsco1 Protein, Gsfsco5 Protein, Gsfsow3 Protein, SCO1 Protein, SCO5 Protein, SOW3 Protein, Ssm Protein, Tr-kit Protein, W Protein, c-KIT Protein, c-kit Protein, MGF Protein, KIT Protein, C-KIT Protein, kit Protein, receptor Protein, sparse Protein, Xkl-1 Protein, kit-a Protein, kit-b Protein, kl1-A Protein, krk1 Protein, pbt Protein, scfr Protein, KIT proto-oncogene receptor tyrosine kinase Protein, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a Protein, KIT proto-oncogene receptor tyrosine kinase S homeolog Protein, KIT Protein, Kit Protein, kita Protein, kit Protein, kit.S Protein

Sujet: KIT, also known as mast/stem cell growth factor receptor Kit isoform 1, is a cytokine receptor that is expressed not only in hematopoietic stem cells but also in other cell types. It binds to receptor tyrosine kinase type III, a stem cell factor, also called a rigid factor or c-kit ligand. When this receptor binds to stem cell factor (SCF), it forms a dimer that activates intrinsic tyrosine kinase activity, which, in turn, phosphorylates and activates signaling molecules that propagate signals in cells. This receptor protects vascular smooth muscle cells from apoptosis and helps restore cardiac function after myocardial infarction. Recombinant human KIT, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 57.1kDa (507aa) 50-70kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_000213

UniProt: P10721

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity