Prolactin Protein (PRL) (AA 29-227) (Fc Tag,AVI tag,Biotin)

N° du produit ABIN5954928

Détail du produit

Antigène: Prolactin (PRL)

Type de proteíne: Recombinant

Attributs du protein: AA 29-227

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette Prolactin protéine est marqué à la Fc Tag,AVI tag,Biotin.

Séquence: AA 29-227

Specificité: Biotinylation of this product is performed using Avitag™ technology. Briefly, the single lysine residue in the Avitag is enzymatically labeled with biotin.

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Commentaires:

Ready-to-use AvitagTM biotinylated protein:
The product is exclusively produced using the AvitagTM technology. Briefly, a unique 15 amino acid peptide, the Avi tag, is introduced into the recombinant protein during expression vector construction. The single lysine residue in the Avi tag is enzymatically biotinylated by the E. Coli biotin ligase BirA.

This single-point enzymatic labeling technique brings many advantages for commonly used binding assays. The biotinylation happens on the lysine residue of Avi tag, and therefore does NOT interfere with the target protein's natural binding activities. In addition, when immobilized on an avidin-coated surface, the protein orientation is uniform because the position of the Avi tag in the protein is precisely controlled.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: Prolactin (PRL)

Autre désignation: Prolactin (PRL Produits)

Synonymes: PRL Protein, prolactin Protein, PRLB Protein, PRLSD1 Protein, Prl1a1 Protein, Prol Protein, RATPRLSD1 Protein, RNPROL Protein, AV290867 Protein, prl Protein, prolactin Protein, prolactin, gene 2 L homeolog Protein, PROLACTIN protein Protein, prolactin-like Protein, PRL Protein, prl.2.L Protein, Prl Protein, LOC100136792 Protein, LOC100136580 Protein, PROLACTIN Protein, LOC101843376 Protein

Sujet: Prolactin (gene name PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females. Prolactin is synthesized as a prohormone. Following cleavage of the signal peptide, the length of the mature hormone is between 194 and 199 amino acids, depending on species. Hormone structure is stabilized by three intramolecular disulfide bonds. Excessive secretion of prolactin - hyperprolactinemia - is a relative common disorder in humans. This condition has numerous causes, including prolactin-secreting tumors and therapy with certain drugs. The prolactin receptor (gene name PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family. Expression of the prolactin receptor is widespread. Each prolactin molecule is thought to bind two receptor molecules

Poids moléculaire: 51.2 kDa

NCBI Accession: NP_000939

Pathways: Signalistation JAK/STAT, Peptide Hormone Metabolism, Response to Growth Hormone Stimulus, Protein targeting to Nucleus