ASRGL1 Protéine

N° du produit ABIN622163

Détail du produit

Antigène: ASRGL1 (Asparaginase Like 1 (ASRGL1))

Reactivité: Veuillez nous consulter SVP

Hôte: Veuillez nous consulter SVP

Attributs du produit: L-Asparaginase

Pureté: > 96.0 % as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: The enzyme was lyophilized with no additives.

Stock: -20 °C

Référence

Yoon, Zapata, Singh, Jo, Spencer, Choi: "Gamma secretase inhibitors enhance vincristine-induced apoptosis in T-ALL in a NOTCH-independent manner." dans: Apoptosis : an international journal on programmed cell death, Vol. 19, Issue 11, pp. 1616-26, (2014) (PubMed).

Détail du antigène

Antigène: ASRGL1 (Asparaginase Like 1 (ASRGL1))

Autre désignation: L-Asparaginase (ASRGL1 Produits)

Synonymes: ASRGL1 Protein, ALP Protein, ALP1 Protein, CRASH Protein, 2410004D18Rik Protein, AU040643 Protein, AW060375 Protein, Gliap Protein, Hiob2 Protein, zgc:103568 Protein, asparaginase like 1 Protein, L-asparaginase Protein, isoaspartyl peptidase/L-asparaginase Protein, ASRGL1 Protein, STY0886 Protein, ansA Protein, ECA0132 Protein, LOC5580113 Protein, EcHS_A0886 Protein, LACBIDRAFT_317700 Protein, BCAM1291 Protein, ZPR_0296 Protein, PAAG_01206 Protein, asrgl1 Protein, Asrgl1 Protein

Sujet: L-Asparaginase produced from E.Coli containing 303 amino acids and having a molecular mass of 31731 Dalton. Introduction: L-Asparaginase is an enzyme that depletes L-Asparagine ,an important nutrient for cancer cells, resulting in cancer/tumor cell starvation. L-asparaginase is an anti-tumor agent derived from E.coli.,which can inhibit the growth of malignant cells. It is used mainly for the induction of remission in acute lymphoblastic leukaemia. Because of the lymph node origin of malignant B cells in Multiple Myeloma, L-Asparagine is an essential amino acid for their cell metabolism, and, consequently, L-Asparaginase may be of value in managing the disease. The rationale behind asparaginase is that it takes advantage of the fact that ALL cellsare unable to synthesize the non-essential amino acidasparaginewhereas normal cells are able to make their own asparagine. These leukemic cells depend on circulating asparagine. Asparaginase however catalyzes the conversion of L-asparagine to aspartic acidand ammonia. This deprives the leukemic cell of circulating asparagine.