BMP2 Protein (AA 289-396) (His tag)
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- Antigène Voir toutes BMP2 Protéines
- BMP2 (Bone Morphogenetic Protein 2 (BMP2))
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 289-396
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Origine
- Humain
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Source
- Escherichia coli (E. coli)
- Purification/Conjugué
- Cette BMP2 protéine est marqué à la His tag.
- Fonction
- BMP-2 (human) (rec.) (His)
- Specificité
- Human BMP-2 (aa 289-396) is fused at the C-terminus to a His-tag.
- Attributs du produit
- Protein. Human BMP-2 (aa 289-396) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: <0.1EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >95 % (SDS-PAGE). Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
- Pureté
- >95 % (SDS-PAGE)
- niveau d'endotoxine
- <0.1EU/μg protein (LAL test, Lonza).
- Top Product
- Discover our top product BMP2 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Concentration
- Lot specific
- Buffer
- Lyophilized from 0.2μm-filtered solution in PBS.
- Conseil sur la manipulation
- Avoid freeze/thaw cycles.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
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- Antigène
- BMP2 (Bone Morphogenetic Protein 2 (BMP2))
- Autre désignation
- BMP-2 (BMP2 Produits)
- Synonymes
- BDA2 Protein, BMP2A Protein, AI467020 Protein, Bmp2a Protein, BMP-2 Protein, xBMP-2 Protein, xbmp2 Protein, BMP2 Protein, bmp2a Protein, bmp2 Protein, wu:fc59d09 Protein, bone morphogenetic protein 2 Protein, bone morphogenetic protein 2 L homeolog Protein, Bone morphogenetic protein 2 Protein, bone morphogenetic protein 2a Protein, BMP2 Protein, Bmp2 Protein, bmp2.L Protein, bmp2 Protein, bmp2a Protein
- Sujet
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Alternate Names/Synonyms: BMP2, Bone Morphogenetic Protein 2
Product Description: Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
- NCBI Accession
- NP_001191
- Pathways
- Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Regulation of Muscle Cell Differentiation, Growth Factor Binding, Positive Regulation of fat Cell Differentiation
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