Liver Arginase Protein (active Mutant)

N° du produit ABIN6253489

Détail du produit

Antigène: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Type de proteíne: Recombinant

Attributs du protein: active Mutant

Origine: Humain

Source: Escherichia coli (E. coli)

Fonction: Arginase I (human) (rec.) (highly active)

Specificité: Full length human arginase I.

Attributs du produit: Protein. Full length human arginase I. Source: E. coli. Liquid. In 10  mM TRIS-HCl,  pH 7.5, containing 1  mM beta-mercaptoethanol, 1  mM MnCl2 and 50 % glycerol. Purity: >90 % (SDS-PAGE). Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.

Pureté: >90 % (SDS-PAGE)

Biological Activity Comment: 1.6 ±0.2U/μg protein. One unit is defined as the amount of enzyme that converts 1μmol of L-arginine to L-ornithine and urea per min. at 37°C, pH 9.5 (according to protocol from R.T. Schimke, et al.; J. Biol. Chem. 238, 1012 (1963)).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. In 10  mM TRIS-HCl,  pH 7.5, containing 1  mM beta-mercaptoethanol, 1  mM MnCl2 and 50 % glycerol.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: -20 °C,-80 °C

Stockage commentaire:

Short Term Storage: -20°C

Long Term Storage: -80°C

Use & Stability: Stable for at least 1 year after receipt when stored at -80°C.

Détail du antigène

Antigène: Liver Arginase (ARG1) (Arginase, Liver (ARG1))

Autre désignation: Arginase I (ARG1 Produits)

Synonymes: SI:zC146F4.4 (novel protein with NUDIX domain) Protein, si:ch211-146f4.3 Protein, argi1 Protein, AI Protein, AI256583 Protein, Arg-1 Protein, PGIF Protein, arginase 1 Protein, arginase Protein, Arginase-1 Protein, arginase, liver Protein, L-arginase Protein, arg1 Protein, PGTG_16455 Protein, argi1 Protein, ARG1 Protein, Arg1 Protein

Sujet:

Alternate Names/Synonyms: EC 3.5.3.1, ARG1, Arginase 1, Type I Arginase, Liver-type Arginase, L-Arginase

Product Description: Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Arginase is involved in the nitric oxide (NO) pathway and immune cell arginine metabolism. It is fundamentally involved in cancer, inflammation, infections, fibrotic diseases, neurobiology, pregnancy and immune regulation in general.

UniProt: P05089

Pathways: Cellular Response to Molecule of Bacterial Origin