CD28 Protein (CD28) (AA 19-152) (Fc Tag)
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- Antigène Voir toutes CD28 Protéines
- CD28
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 19-152
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Origine
- Humain, Cynomolgus, Macaque rhésus
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD28 protéine est marqué à la Fc Tag.
- Séquence
- AA 19-152
- Attributs du produit
- This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 42.0 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 0.1 EU per μg by the LAL method.
- Top Product
- Discover our top product CD28 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM Glycine, pH 7.5
- Conseil sur la manipulation
- Please avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." dans: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways." dans: Immunity, Vol. 51, Issue 6, pp. 1059-1073.e9, (2019) (PubMed).
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- Antigène
- CD28
- Autre désignation
- CD28 (CD28 Produits)
- Synonymes
- Tp44 Protein, CD28RNA Protein, cd28 Protein, CD28 molecule Protein, CD28 antigen Protein, Cd28 molecule Protein, CD28 molecule L homeolog Protein, CD28 Protein, Cd28 Protein, cd28.L Protein
- Sujet
- T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
- Poids moléculaire
- 42.0 kDa
- NCBI Accession
- NP_006130
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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