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CADM1 Protein (AA 45-374) (His tag)
CADM1
Origine: Humain
Hôte: Escherichia coli (E. coli)
Recombinant
> 85 % by SDS - PAGE
SDS
N° du produit ABIN6387491
Détail du produit
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Antigène
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CADM1
(Cell Adhesion Molecule 1 (CADM1))
Type de proteíne
Recombinant
Attributs du protein
AA 45-374
Origine
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Humain
Source
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Escherichia coli (E. coli)
Purification/Conjugué
Cette CADM1 protéine est marqué à la His tag.
Application
SDS-PAGE (SDS)
Séquence
MGSSHHHHHH SSGLVPRGSH MGSQNLFTKD VTVIEGEVAT ISCQVNKSDD SVIQLLNPNR QTIYFRDFRP LKDSRFQLLN FSSSELKVSL TNVSISDEGR YFCQLYTDPP QESYTTITVL VPPRNLMIDI QKDTAVEGEE IEVNCTAMAS KPATTIRWFK GNTELKGKSE VEEWSDMYTV TSQLMLKVHK EDDGVPVICQ VEHPAVTGNL QTQRYLEVQY KPQVHIQMTY PLQGLTREGD ALELTCEAIG KPQPVMVTWV RVDDEMPQHA VLSGPNLFIN NLNKTDNGTY RCEASNIVGK AHSDYMLYVY DPPTTIPPPT TTTTTTTTTT TTILTIITDS RAGEEGSIRA VDH
Pureté
> 85 % by SDS - PAGE
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
Liquid. In Phosphate buffered saline ( pH 7.4) containing 10 % glycerol, 1 mM DTT
Stock
4 °C,-20 °C,-80 °C
Stockage commentaire
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Détail du antigène
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Antigène
CADM1
(Cell Adhesion Molecule 1 (CADM1))
Autre désignation
CADM1 (CADM1 Produits )
Synonymes
BL2 Protein, IGSF4 Protein, IGSF4A Protein, NECL2 Protein, Necl-2 Protein, RA175 Protein, ST17 Protein, SYNCAM Protein, TSLC1 Protein, sTSLC-1 Protein, sgIGSF Protein, synCAM1 Protein, bl2 Protein, igsf4 Protein, igsf4a Protein, necl-2 Protein, necl2 Protein, ra175 Protein, sgigsf Protein, st17 Protein, stslc-1 Protein, syncam Protein, syncam1 Protein, tslc1 Protein, xnecl2 Protein, 2900073G06Rik Protein, 3100001I08Rik Protein, AI987920 Protein, Bl2 Protein, Igsf4 Protein, Igsf4a Protein, Necl2 Protein, RA175A Protein, RA175B Protein, RA175C Protein, RA175N Protein, SgIGSF Protein, SynCam Protein, Tslc1 Protein, SynCAM1 Protein, cell adhesion molecule 1 Protein, cell adhesion molecule 1 L homeolog Protein, CADM1 Protein, cadm1.L Protein, Cadm1 Protein
Sujet
CADM1 mediates homophilic cell-cell adhesion in a Ca2+-independent manner and also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. This protein acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Recombinant human CADM1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Poids moléculaire
39.4 kDa (353aa) confirmed by MALDI-TOF
NCBI Accession
NP_055148
UniProt
Q9BY67
Pathways
Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Cell-Cell Junction Organization , Activated T Cell Proliferation
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