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PLAT Protein (AA 311-562) (His tag)
PLAT
Origine: Humain
Hôte: Baculovirus infected Insect Cells
Recombinant
> 90 % by SDS - PAGE
SDS
N° du produit ABIN6387935
Détail du produit
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Antigène
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PLAT
(Plasminogen Activator, Tissue (PLAT))
Type de proteíne
Recombinant
Attributs du protein
AA 311-562
Origine
Toutes les origines à travers PLAT Protéines
Humain
Source
Toutes les sources à travers PLAT Protéines
Baculovirus infected Insect Cells
Purification/Conjugué
Cette PLAT protéine est marqué à la His tag.
Application
SDS-PAGE (SDS)
Séquence
QEIHARFRRG ARSYQVICRD EKTQMIYQQH QSWLRPVLRS NRVEYCWCNS GRAQCHSVPV KSCSEPRCFN GGTCQQALYF SDFVCQCPEG FAGKCCEIDT RATCYEDQGI SYRGTWSTAE SGAECTNWNS SALAQKPYSG RRPDAIRLGL GNHNYCRNPD RDSKPWCYVF KAGKYSSEFC STPACSEGNS DCYFGNGSAY RGTHSLTESG ASCLPWNSMI LIGKVYTAQN PSAQALGLGK HNYCRNPDGD AKPWCHVLKN RRLTWEYCDV PSCSTCGLRQ YSQPQFRIKG GLFADIASHP WQAAIFAKHR RSPGERFLCG GILISSCWIL SAAHCFQERF PPHHLTVILG RTYRVVPGEE EQKFEVEKYI VHKEFDDDTY DNDIALLQLK SDSSRCAQES SVVRTVCLPP ADLQLPDWTE CELSGYGKHE ALSPFYSERL KEAHVRLYPS SRCTSQHLLN RTVTDNMLCA GDTRSGGPQA NLHDACQGDS GGPLVCLNDG RMTLVGIISW GLGCGQKDVP GVYTKVTNYL DWIRDNMRPH HHHHH
Pureté
> 90 % by SDS - PAGE
niveau d'endotoxine
< 1.0 EU per 1 microgram of protein (determined by LAL method)
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
Liquid. In 50 mM MES buffer ( pH 5.5) containing 40 % glycerol, 5 mM CaCl2, 1 mM DTT, 0.5M NaCl.
Stock
4 °C,-20 °C,-80 °C
Stockage commentaire
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Détail du antigène
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Antigène
PLAT
(Plasminogen Activator, Tissue (PLAT))
Autre désignation
PLAT (PLAT Produits )
Synonymes
T-PA Protein, TPA Protein, AU020998 Protein, AW212668 Protein, D8Ertd2e Protein, tPA Protein, PATISS Protein, tpa Protein, Plat Protein, plat Protein, t-pa Protein, plasminogen activator, tissue type Protein, plasminogen activator, tissue Protein, chromosome 20 open reading frame 181 Protein, plasminogen activator, tissue L homeolog Protein, PLAT Protein, Plat Protein, plat Protein, C20orf181 Protein, plat.L Protein
Sujet
PLAT, as known as tissue-type plasminogen activator isoform 1, is a secreted serine protease synthesized by endothelial cells. This protein is secreted as a single chain polypeptide precursor which is cleaved in turn by plasmin. Also, it plays a role clinical medicine to treat stroke in cell migration and tissue remodeling. It is implicated in normal neural function and is suggested as a regulatory molecule in neurodegenerative diseases. Recombinant human PLAT, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Poids moléculaire
61.3kDa (545aa) 50-70kDa (SDS-PAGE under reducing conditions.)
NCBI Accession
NP_000921
UniProt
P00750
Pathways
Autophagy , Smooth Muscle Cell Migration , Platelet-derived growth Factor Receptor Signaling , SARS-CoV-2 Protein Interactome
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