zgc:73302 Protein, wu:fj61c06 Protein, VAMP2 Protein, vamp2-a Protein, xsybi Protein, Syb-2 Protein, Syb2 Protein, sybII Protein, RATVAMPB Protein, RATVAMPIR Protein, SYB Protein, SYB2 Protein, VAMP-2 Protein, syb2 Protein, vamp2 Protein, xsybii Protein, vesicle-associated membrane protein 2 Protein, vesicle associated membrane protein 2 Protein, vesicle associated membrane protein 2 S homeolog Protein, vesicle-associated membrane protein 2 (synaptobrevin 2) Protein, vesicle associated membrane protein 2 L homeolog Protein, vamp2 Protein, VAMP2 Protein, vamp2.S Protein, Vamp2 Protein, vamp2.L Protein
Sujet
Vamp2, also known as Vesicle-associated membrane protein 2, is involved in the targeting and/or fusion of transport vesicles to their target membrane. It modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Vamp2 proteins localized to the cytoplasmic surface of synaptic vesicle, consists of a proline-rich N-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a C-terminal. This proteins also known to mediate cAMP-stimulated exocytosis in nerve cells and in renal cells of the juxtaglomerular apparatus. Recombinant mouse Vamp2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography