KIR2DL4/CD158d Protein (AA 24-242) (hIgG-His-tag)

N° du produit ABIN6388078

Détail du produit

Antigène: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Type de proteíne: Recombinant

Attributs du protein: AA 24-242

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette KIR2DL4/CD158d protéine est marqué à la hIgG-His-tag.

Application: SDS-PAGE (SDS)

Séquence: HVGGQDKPFC SAWPSAVVPQ GGHVTLRCHY RRGFNIFTLY KKDGVPVPEL YNRIFWNSFL ISPVTPAHAG TYRCRGFHPH SPTEWSAPSN PLVIMVTGLY EKPSLTARPG PTVRAGENVT LSCSSQSSFD IYHLSREGEA HELRLPAVPS INGTFQADFP LGPATHGETY RCFGSFHGSP YEWSDPSDPL PVSVTGNPSS SWPSPTEPSF KTGIARHLHL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH

Pureté: > 85 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: KIR2DL4/CD158d (KIR2DL4) (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4))

Autre désignation: KIR2DL4 (KIR2DL4 Produits)

Synonymes: G9P Protein, CD158D Protein, KIR103 Protein, KIR103AS Protein, KIR2DL4 Protein, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Protein, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 Protein, KIR2DL4 Protein

Sujet: KIR2DL4, also known as killer cell immunoglobulin-like receptor 2DL4, is a member of the killer cell Ig-like receptor (KIR) family. KIR proteins with the long cytoplasmic domain transduce inhibitory signals via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. This protein induces NK cells to produce IFN-gamma and stimulation with IL-2 upregulates cell surface expression on CD56dim cells and leads to the inhibition of the cytolytic NK cell function. Recombinant human KIR2DL4 protein, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 51.0kDa (458aa) 50-70KDa (SDS-PAGE under reducing conditions.)

NCBI Accession: NP_002246

UniProt: Q99706