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UMPS Protein (AA 1-480) (His tag)
UMPS
Origine: Humain
Hôte: Baculovirus infected Insect Cells
Recombinant
> 95 % by SDS - PAGE
SDS
N° du produit ABIN6388096
Détail du produit
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Antigène
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UMPS
(Uridine Monophosphate Synthetase (UMPS))
Type de proteíne
Recombinant
Attributs du protein
AA 1-480
Origine
Toutes les origines à travers UMPS Protéines
Humain
Source
Toutes les sources à travers UMPS Protéines
Baculovirus infected Insect Cells
Purification/Conjugué
Cette UMPS protéine est marqué à la His tag.
Application
SDS-PAGE (SDS)
Séquence
MAVARAALGP LVTGLYDVQA FKFGDFVLKS GLSSPIYIDL RGIVSRPRLL SQVADILFQT AQNAGISFDT VCGVPYTALP LATVICSTNQ IPMLIRRKET KDYGTKRLVE GTINPGETCL IIEDVVTSGS SVLETVEVLQ KEGLKVTDAI VLLDREQGGK DKLQAHGIRL HSVCTLSKML EILEQQKKVD AETVGRVKRF IQENVFVAAN HNGSPLSIKE APKELSFGAR AELPRIHPVA SKLLRLMQKK ETNLCLSADV SLARELLQLA DALGPSICML KTHVDILNDF TLDVMKELIT LAKCHEFLIF EDRKFADIGN TVKKQYEGGI FKIASWADLV NAHVVPGSGV VKGLQEVGLP LHRGCLLIAE MSSTGSLATG DYTRAAVRMA EEHSEFVVGF ISGSRVSMKP EFLHLTPGVQ LEAGGDNLGQ QYNSPQEVIG KRGSDIIIVG RGIISAADRL EAAEMYRKAA WEAYLSRLGV HHHHHH
Pureté
> 95 % by SDS - PAGE
niveau d'endotoxine
< 1.0 EU per 1ug of protein (determined by LAL method)
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
Liquid. In Phosphate Buffered Saline ( pH 7.4).
Stock
4 °C,-20 °C,-80 °C
Stockage commentaire
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Détail du antigène
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Antigène
UMPS
(Uridine Monophosphate Synthetase (UMPS))
Autre désignation
UMPS (UMPS Produits )
Synonymes
zgc:55702 Protein, zgc:55723 Protein, UMPS Protein, OPRT Protein, 1700095D23Rik Protein, AA408257 Protein, AL033308 Protein, BB164745 Protein, Orotidine 5'-phosphate decarboxylase Protein, uridine monophosphate synthetase Protein, uridine monophosphate synthetase L homeolog Protein, uridine 5'-monophosphate synthase Protein, umps-1 Protein, umps Protein, umps.L Protein, UMPS Protein, LOC100556619 Protein, Umps Protein
Sujet
UMPS, also known as uridine 5'-monophosphate synthase, is a bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis. It is an indispensable component in this metabolic pathway and is a target for antimalarial and antitumor drugs. Its expression in colorectal carcinoma tissues is not correlated with the toxicities of 5-FU-based regimen, but It in the normal tissues can help predict the toxicities associated with 5-FU. Recombinant human UMPS, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Poids moléculaire
53kDa (486aa) 50-70kDa (SDS-PAGE under reducing conditions)
NCBI Accession
NP_000364
UniProt
P11172
Pathways
Ribonucleoside Biosynthetic Process
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