FCER2 Protein (AA 48-321) (His tag)

N° du produit ABIN7281312

Détail du produit

Antigène: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Type de proteíne: Recombinant

Attributs du protein: AA 48-321

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette FCER2 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: ADPDTTQSLK QLEERAARNV SQVSKNLESH HGDQMAQKSQ STQISQELEE LRAEQQRLKS QDLELSWNLN GLQADLSSFK SQELNERNEA SDLLERLREE VTKLRMELQV SSGFVCNTCP EKWINFQRKC YYFGKGTKQW VHARYACDDM EGQLVSIHSP EEQDFLTKHA SHTGSWIGLR NLDLKGEFIW VDGSHVDYSN WAPGEPTSRS QGEDCVMMRG SGRWNDAFCD RKLGAWVCDR LATCTPPASE GSAESMGPDS RPDPDGRLPT PSAPLHSHHH HHH

Pureté: > 90 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))

Autre désignation: FCER2 (FCER2 Produits)

Synonymes: BLAST-2 Protein, CD23 Protein, CD23A Protein, CLEC4J Protein, FCE2 Protein, IGEBF Protein, Fcer2a Protein, Fc fragment of IgE receptor II Protein, FCER2 Protein, Fcer2 Protein

Sujet: FCER2, also known as low affinity immunoglobulin epsilon Fc receptor isoform a, is a member of subgroup II of the C-type (Ca++-dependent) lectin superfamily. It is a low affinity receptor for B cell specific antigen and IgE. It plays an essential role in the growth and differentiation of B cells, and in the regulation of IgE production. This protein also exists in a soluble secretion form and functions as a powerful cleavage-promoting growth factor. Increased levels of soluble CD23 / FCER2 lead to the recruitment of unaffected B cells in the presentation of antigen peptides to allergen-specific B cells. Recombinant human FCER2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 32.0kDa (283aa) 28-40kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_001993

UniProt: P06734

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process