COLEC7 Protein, PSP-D Protein, SFTP4 Protein, SP-D Protein, BDE Protein, BDSD Protein, HOX4I Protein, SPD Protein, AI573415 Protein, Sftp4 Protein, surfactant protein D Protein, homeobox D13 Protein, surfactant associated protein D Protein, SFTPD Protein, HOXD13 Protein, Sftpd Protein, SP-D Protein
Sujet
CD52, also known as CAMPATH-1 antigen, is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein that is tethered to the cell surface with a GPI linkage. This protein can be targeted to induce immune suppression by complement-meditated cell lysis. CD52 is expressed on lymphocytes, monocytes, monocytes-derived dendritic cells, eosinophils, and neutrophils, but not on the stem cells from which these lymphocytes were derived. Also, it is an important target for therapeutic interventions aimed at leukocyte depletion in hematological malignancies and post-transplant immunosuppression. Recombinant human CD52, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Poids moléculaire
28.2kDa (251aa) 28-40kDa (SDS-PAGE under reducing conditions)