FRZB Protein (AA 33-325) (His tag)

N° du produit ABIN6388237

Détail du produit

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Type de proteíne: Recombinant

Attributs du protein: AA 33-325

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette FRZB protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: ADPAACEPVR IPLCKSLPWN MTKMPNHLHH STQANAILAI EQFEGLLGTH CSPDLLFFLC AMYAPICTID FQHEPIKPCK SVCERARQGC EPILIKYRHS WPENLACEEL PVYDRGVCIS PEAIVTADGA DFPMDSSNGN CRGASSERCK CKPIRATQKT YFRNNYNYVI RAKVKEIKTK CHDVTAVVEV KEILKSSLVN IPRDTVNLYT SSGCLCPPLN VNEEYIIMGY EDEERSRLLL VEGSIAEKWK DRLGKKVKRW DMKLRHLGLS KSDSSNSDST QSQKSGRNSN PRQARNHHHH HH

Pureté: > 90 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 10 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: FRZB (Frizzled-Related Protein (FRZB))

Autre désignation: FRZB (FRZB Produits)

Synonymes: Frp Protein, Sfrp3 Protein, frezzled Protein, fritz Protein, frzb-1 Protein, FRE Protein, FRITZ Protein, FRP-3 Protein, FRZB-1 Protein, FRZB-PEN Protein, FRZB1 Protein, FZRB Protein, OS1 Protein, SFRP3 Protein, SRFP3 Protein, hFIZ Protein, Frzb-1 Protein, frizzled-related protein Protein, Frzb Protein, FRZB Protein

Sujet: FRZB, also known as secreted frizzled-related protein 3, is a member of the family of Wnt-binding proteins with homology to the ligand binding domain of the Frizzled receptors. It is widely expressed in adult mammalian tissues and in chondrocytes. It is a key factors in blocking hypertrophic differentiation of human MSCs (hMSCs) and important in skeletal development in the embryo and fetus. It acts as an agonist of Wnt signaling and promotes invasive behavior. It has a role in regulating cell growth and differentiation in specific cell types. It also functions as a tumor suppressor in a variety of cancers. Recombinant human FRZB, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 34.2kDa (302aa) 28-40kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_001454

UniProt: Q92765

Pathways: Signalisation WNT, Positive Regulation of fat Cell Differentiation