HLA-DRB1 Protein (AA 30-227) (His tag)

N° du produit ABIN6388240

Détail du produit

Antigène: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Type de proteíne: Recombinant

Attributs du protein: AA 30-227

Origine: Humain

Source: Baculovirus infected Insect Cells

Purification/Conjugué: Cette HLA-DRB1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Séquence: ADPGDTRPRF LWQPKRECHF FNGTERVRFL DRYFYNQEES VRFDSDVGEF RAVTELGRPD AEYWNSQKDI LEQARAAVDT YCRHNYGVVE SFTVQRRVQP KVTVYPSKTQ PLQHHNLLVC SVSGFYPGSI EVRWFLNGQE EKAGMVSTGL IQNGDWTFQT LVMLETVPRS GEVYTCQVEH PSVTSPLTVE WRARSESAQS KHHHHHH

Pureté: > 85 % by SDS - PAGE

niveau d'endotoxine: < 1.0 EU per 1ug of protein (determined by LAL method)

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 30 % glycerol.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: HLA-DRB1 (Major Histocompatibility Complex, Class II, DR beta 1 (HLA-DRB1))

Autre désignation: HLA-DRB1 (HLA-DRB1 Produits)

Synonymes: MGC108235 Protein, DRB1 Protein, DRw10 Protein, HLA-DR1B Protein, HLA-DRB Protein, SS1 Protein, major histocompatibility complex, class II, DR beta 1 Protein, hla-drb1 Protein, HLA-DRB1 Protein

Sujet: HLA-DRB1, also known as major histocompatibility complex, class II, DR beta 1 precursor, belongs to the human leukocyte antigen (HLA) class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins to T helper cells. It helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. It is associated with an increased incidence of rheumatoid arthritis. Recombinant human HLA-DRB1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Poids moléculaire: 24.0kDa (207aa) 28-40kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_002115

UniProt: Q29974

Pathways: TCR Signaling, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, CXCR4-mediated Signaling Events, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response