Growth differentiation factor 15 (GDF-15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. This protein is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 was expressed in E.coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer. Synonyms: GDF15, GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB, Growth differentiation factor 15 NSAID regulated protein 1, Placental TGF beta, GDF 15, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC 1, NAG 1, NAG1, NRG 1, NRG1, NSAID, NSAID (nonsteroidal anti inflammatory drug) activated protein 1, Placental bone morphogenetic protein, Placental bone morphogenic protein, Prostate differentiation factor, PTGF beta, PTGFB. NCBI no.: NP_004855
Poids moléculaire
16.7 kDa (151aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)