Prealbumin, also known Transthyretin, is a tetrameric human plasma protein that is synthesized mainly in the liver. This protein transports the thyroid hormone thyroxine (T4) and retinol (Vitamin A). It is the best indicator of protein-energy malnutrition because it has a circulating half life of 2 days and responds rapidly to changes in nutritional status. Also point-mutations of its gene are known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC). Recombinant human Prealbumin was expressed in E.coli and purified by using conventional chromatography. Synonyms: TTR, Transthyretin, TBPA, ATTR, PALB, Amyloid polyneuropathy, Amyloidosis I, Dysprealbuminemic euthyroidal hyperthyroxinemia, Dystransthyretinemic hyperthyroxinemia, HsT2651, Prealbumin amyloidosis type I, Senile systemic amyloidosis, TTR protein. NCBI no.: NP_000362