MGC75890 Protein, snip1a Protein, SNIP1 Protein, PMRED Protein, 2410133M08Rik Protein, Smad nuclear interacting protein 1 Protein, Smad nuclear interacting protein 1 S homeolog Protein, smad nuclear interacting protein 1 Protein, MYST/Esa1 associated factor 6 Protein, snip1 Protein, snip1.S Protein, SNIP1 Protein, CC1G_02914 Protein, PTRG_06240 Protein, MEAF6 Protein, Snip1 Protein
Sujet
SNIP1 is smad nuclear interacting protein contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signal transduction pathway and to be important in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for binding to p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. Recombinant human SNIP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Smad nuclear interacting protein 1, FLJ12553, Splicing factor arginine/serine rich 4. NCBI no.: NP_078976