TIP-1 Protein, 1300011C24Rik Protein, RP23-263M10.10 Protein, tax1bp3 Protein, wu:fb37e03 Protein, wu:fc23g08 Protein, zgc:55513 Protein, Tax1 binding protein 3 Protein, Tax1 (human T cell leukemia virus type I) binding protein 3 Protein, Tax1 (human T-cell leukemia virus type I) binding protein 3 S homeolog Protein, Tax1 (human T-cell leukemia virus type I) binding protein 3 Protein, TAX1BP3 Protein, Tax1bp3 Protein, tax1bp3.S Protein, tax1bp3 Protein
Sujet
TAX1BP3, also known as Tax1-binding protein 3, contains one PDZ domain, through which most of its interactions with other proteins are made. The PDZ domain of TAX1BP3 interacts with the C-terminus of Rhotekin to facilitate Rho-mediated activation of the FOS serum response element. The PDZ domain also interacts with beta-catenin to inhibit the transcriptional activity of beta-catenin. It has been detected in a variety of cell lines, including HeLa, and is weakly expressed in peripheral blood leukocytes. Recombinant human TAX1BP3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Tax1-binding protein 3, TIP-1, TIP1. NCBI no.: NP_055419