IL23R Protein (AA 24-355) (Fc Tag)

N° du produit ABIN6809891

Détail du produit

Antigène: IL23R (Interleukin 23 Receptor (IL23R))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 24-355

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette IL23R protéine est marqué à la Fc Tag.

Séquence: AA 24-355

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Conseil sur la manipulation: Please avoid repeated freeze-thaw cycles.

Stock: -20 °C

Détail du antigène

Antigène: IL23R (Interleukin 23 Receptor (IL23R))

Autre désignation: IL-23R (IL23R Produits)

Synonymes: IL-23R Protein, IL23R Protein, il-23r Protein, interleukin 23 receptor Protein, IL23R Protein, il23r Protein, Il23r Protein

Sujet: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Poids moléculaire: 64.5 kDa

NCBI Accession: NP_653302

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation