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Insulin Receptor Protein (INSR) (AA 28-944) (His tag)
INSR
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
N° du produit ABIN6809906
Détail du produit
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Antigène
Voir toutes Insulin Receptor (INSR) Protéines
Insulin Receptor (INSR)
Type de proteíne
Recombinant
Activité biologique
Active
Attributs du protein
AA 28-944
Origine
Toutes les origines à travers Insulin Receptor Protéines
Humain
Source
Toutes les sources à travers Insulin Receptor Protéines
HEK-293 Cells
Purification/Conjugué
Cette Insulin Receptor protéine est marqué à la His tag.
Séquence
AA 28-944
Pureté
>90 % as determined by SDS-PAGE.
niveau d'endotoxine
Less than 1.0 EU per μg by the LAL method.
Alternatives
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Information d'application
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Restrictions
For Research Use only
Stockage
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Format
Lyophilized
Buffer
PBS, pH 7.4
Conseil sur la manipulation
Please avoid repeated freeze-thaw cycles.
Stock
-20 °C
Détail du antigène
(cache)
Antigène
Insulin Receptor (INSR)
Autre désignation
Insulin R (INSR Produits )
Synonymes
CD220 Protein, HHF5 Protein, 4932439J01Rik Protein, D630014A15Rik Protein, IR Protein, IR-A Protein, IR-B Protein, 18402 Protein, CG18402 Protein, DIHR Protein, DILR Protein, DIR Protein, DIRH Protein, DIRbeta Protein, DInR Protein, DInr Protein, Dir-a Protein, Dir-b Protein, Dmel\\CG18402 Protein, INR Protein, INS Protein, Inr Protein, Inr-alpha Protein, Inr-beta Protein, InsR Protein, dINR Protein, dIR Protein, dIRH Protein, dInR Protein, dInr Protein, dInsR Protein, dinr Protein, dir Protein, er10 Protein, inr Protein, insulin/insulin-like growth factor receptor Protein, l(3)05545 Protein, l(3)93Dj Protein, l(3)er10 Protein, lnR Protein, ir-A Protein, CTK-1 Protein, ir Protein, INSR Protein, NV14476 Protein, cd220 Protein, hhf5 Protein, insulin receptor Protein, Insulin-like receptor Protein, insulin receptor L homeolog Protein, INSR Protein, Insr Protein, InR Protein, LOC100122567 Protein, LOC100451802 Protein, insr.L Protein
Sujet
Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.
Poids moléculaire
106.5 kDa
NCBI Accession
NP_000199
Pathways
Signalisation NF-kappaB , Signalisation RTK , AMPK Signaling , Carbohydrate Homeostasis , Regulation of Cell Size , Regulation of Carbohydrate Metabolic Process , Growth Factor Binding , Negative Regulation of Transporter Activity
Vus récemment
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