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tau Protein (partial, Pro301Leu-Mutant)

Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant SDS, WB, in vitro, in vivo Active
N° du produit ABIN6929400
  • Antigène Voir toutes tau Protéines
    tau (tau Protein)
    Type de proteíne
    Recombinant
    Activité biologique
    Active
    Attributs du protein
    Pro301Leu-Mutant, partial
    Origine
    • 10
    • 3
    • 1
    • 1
    Humain
    Source
    • 14
    • 1
    Escherichia coli (E. coli)
    Application
    SDS-PAGE (SDS), Western Blotting (WB), In vitro Assay (in vitro), In vivo Studies (in vivo)
    Fonction
    Active Human Recombinant Tau (K18), P301L mutant Protein Pre-formed Fibrils
    Séquence
    SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV LGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE
    Specificité
    ~15.1 kDa
    Purification
    Ion-exchange Purified
    Biological Activity Comment
    Thioflavin T emission curve shows increased fluorescence (correlated to tau protein fibrillation) when active tau PFFs are combined with active tau monomers.
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    Lot specific
    Buffer
    10 mM HEPES, 100 mM NaCl pH 7.4
    Stock
    -80 °C
  • Antigène
    tau (tau Protein)
    Autre désignation
    Tau (tau Produits)
    Synonymes
    DDPAC Protein, FTDP-17 Protein, MAPTL Protein, MSTD Protein, MTBT1 Protein, MTBT2 Protein, PPND Protein, TAU Protein, tau Protein, PHF-tau Protein, microtubule associated protein tau Protein, MAPT Protein
    Sujet
    Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10 % of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R) (4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).
    UniProt
    P10636
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