CXCL12
Origine: Souris
Hôte: Escherichia coli (E. coli)
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Spin tube prior to resuspending. Recommended at 100 μg/mL in sterile water
Stock
-20 °C,-80 °C
Stockage commentaire
12 months from date of receipt, -20 to -70 °C as supplied. Suggest to use immediately after reconstitution 1 month at -20 to -70 °C under sterile conditions after reconstitution.
Stromal-Cell Derived Factor-1alpha (SDF-1alpha) (CXCL12) attracts lymphocytes and plays important roles in embryogenesis and angiogenesis with implications in tumor metastasis. By binding to CXCR4, one of the co-receptors for HIV viral entry, SDF-1alpha can suppress HIV. Besides CXCR4, SDF-1alpha also binds to the “decoy” receptor CXCR7, and activates the downstream beta-arrestin- rather than G protein-mediated signaling pathway.