CD33 Protein (CD33) (AA 18-259) (Fc-His Tag)
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- Antigène Voir toutes CD33 Protéines
- CD33
- Type de proteíne
- Recombinant
- Attributs du protein
- AA 18-259
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette CD33 protéine est marqué à la Fc-His Tag.
- Fonction
- Recombinant human CD33 protein with C-terminal human Fc and 6xHis tag
- Specificité
- CD33 (Asp18-His259) hFc (Glu99-Ala330) 6xHis tag
- Attributs du produit
- Extracellular Domain Protein
- Purification
- Purified from cell culture supernatant by affinity chromatography
- Pureté
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
- Top Product
- Discover our top product CD33 Protéine
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- Date de péremption
- 12 months
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- Antigène
- CD33
- Autre désignation
- CD33 (CD33 Produits)
- Synonymes
- SIGLEC-3 Protein, SIGLEC3 Protein, p67 Protein, Siglec-3 Protein, gp67 Protein, CD33 molecule Protein, CD33 antigen Protein, CD33 Protein, Cd33 Protein
- Sujet
- Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2, 3- and more avidly alpha-2, 6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.
- Poids moléculaire
- predicted molecular mass of 53.8 kDa after removal of the signal peptide.
- ID gène
- 945
- UniProt
- P20138
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