CD46 Protein (CD46) (AA 35-328) (His tag)

N° du produit ABIN6964079

Détail du produit

Antigène: CD46

Type de proteíne: Recombinant

Attributs du protein: AA 35-328

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette CD46 protéine est marqué à la His tag.

Fonction: Recombinant human CD46 Protein with C-terminal 6xHis tag

Specificité: CD46 (Cys35-Asp328) 6xHis tag

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CD46

Autre désignation: CD46 (CD46 Produits)

Synonymes: AHUS2 Protein, MCP Protein, MIC10 Protein, TLX Protein, TRA2.10 Protein, Mcp Protein, CD46 Protein, CD46 molecule Protein, CD46 antigen, complement regulatory protein Protein, CD46 molecule, complement regulatory protein Protein, membrane cofactor protein-like Protein, CD46 Protein, Cd46 Protein, LOC100341359 Protein, LOC103789310 Protein

Sujet: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Poids moléculaire: predicted molecular mass of 33.5 kDa after removal of the signal peptide.The apparent molecular mass of CD46-His is 55-70 kDa due to glycosylation.

ID gène: 4179

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization