CD8 alpha Protein (AA 22-182) (Fc Tag)

N° du produit ABIN6964139

Protéine Recombinant CD8 alpha exprimée dans HEK-293 Cells.

Aperçu rapide pour CD8 alpha Protein (AA 22-182) (Fc Tag) (ABIN6964139)

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Application: Affinity Measurement (AM), Antibody Drug Assay (ADA), Immunoassay (IA), Screening Assay (ScA)

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Détail du produit

Attributs du protein: AA 22-182

Purification/Conjugué: Cette CD8 alpha protéine est marqué à la Fc Tag.

Fonction: Recombinant human CD8A Acidic tail Protein with C-terminal human Fc tag

Specificité: CD8A(Ser22-Asp182) Acidic tail hFc(Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: affinity purification

Information d'application

Indications d'application: Extracellular Domain Proteins (ECD) can be used as:

• Immunogens for antibody drug development
• Reagents used for CAR-T positive cell monitoring
• Reagents for antibody screening and functional testing
• Reagents for antibody affinity measurement

Commentaires:

The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Please see Certificate of Analysis for specific instructions of reconstitution.

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Autre désignation: CD8A

Sujet: CD8, p32, Leu2, IMD116, CD8alpha
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]

Poids moléculaire: predicted molecular mass of 44.8 kDa after removal of the signal peptide.

UniProt: P01732

Pathways: TCR Signaling