NLRP3 Protein (AA 2-1036) (DYKDDDDK Tag)

N° du produit ABIN6964301

Détail du produit

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Type de proteíne: Recombinant

Attributs du protein: AA 2-1036

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette NLRP3 protéine est marqué à la DYKDDDDK Tag.

Fonction: Recombinant Human NLRP3 with C-terminal Flag tag

Specificité: NLRP3 (Lys2-Trp1036) Flag

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Autre désignation: NLRP3 (NLRP3 Produits)

Synonymes: CIAS1 Protein, Nalp3 Protein, avp Protein, cias1 Protein, nalp3 Protein, pypaf1 Protein, agtavprl Protein, AGTAVPRL Protein, AII Protein, AVP Protein, C1orf7 Protein, CLR1.1 Protein, FCAS Protein, FCU Protein, MWS Protein, NALP3 Protein, PYPAF1 Protein, AII/AVP Protein, Cias1 Protein, Mmig1 Protein, Pypaf1 Protein, NLR family pyrin domain containing-like Protein, NLR family pyrin domain containing 3 Protein, NLR family, pyrin domain containing 3 L homeolog Protein, NLR family, pyrin domain containing 3 Protein, NLRPL Protein, NLRP3 Protein, nlrp3.L Protein, Nlrp3 Protein

Sujet: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

Poids moléculaire: predicted molecular mass of 121.8 kDa after removal of the signal peptide.

UniProt: Q96P20

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome