FLT1 Protein (AA 27-756) (Fc Tag)

N° du produit ABIN6964344

Détail du produit

Antigène: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Type de proteíne: Recombinant

Attributs du protein: AA 27-756

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette FLT1 protéine est marqué à la Fc Tag.

Fonction: Recombinant human FLT1 protein with C-terminal human Fc tag

Specificité: FLT1 (Ser27-Asn756) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Autre désignation: FLT1 (FLT1 Produits)

Synonymes: FLT Protein, FLT-1 Protein, VEGFR-1 Protein, VEGFR1 Protein, FLT1 Protein, flt1b Protein, sFlt1 Protein, AI323757 Protein, Flt-1 Protein, fms related tyrosine kinase 1 Protein, FMS-related tyrosine kinase 1 Protein, vascular endothelial growth factor receptor 1 Protein, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) Protein, FMS-like tyrosine kinase 1 Protein, vascular endothelial growth factor receptor-1 Protein, FLT1 Protein, Flt1 Protein, CpipJ_CPIJ012087 Protein, flt1 Protein, FLT-1 Protein

Sujet: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

Poids moléculaire: predicted molecular mass of 108.3 kDa after removal of the signal peptide. The apparent molecular mass of FLT1-hFc is 130-180 kDa due to glycosylation.

UniProt: P17948

Pathways: Signalisation RTK, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals