GDF2 Protein (AA 320-429)

N° du produit ABIN6973076

Détail du produit

Antigène: GDF2 (Growth Differentiation Factor 2 (GDF2))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 320-429

Origine: Humain

Source: HEK-293 Cells

Attributs du produit: Human GDF-2 Protein, Tag Free

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: ACN, TFA in Water

Stock: -20 °C

Détail du antigène

Antigène: GDF2 (Growth Differentiation Factor 2 (GDF2))

Autre désignation: GDF-2 (GDF2 Produits)

Synonymes: bmp9 Protein, BMP-9 Protein, BMP9 Protein, Bmp9 Protein, DSL1 Protein, growth differentiation factor 2 Protein, gdf2 Protein, GDF2 Protein, Gdf2 Protein

Sujet: Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.

Poids moléculaire: 12.1 kDa

Pathways: Transition Metal Ion Homeostasis