C5 Protein (AA 19-1680) (His tag)
-
- Antigène Voir toutes C5 Protéines
- C5 (Complement Component 5 (C5))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 19-1680
-
Origine
- Souris
-
Source
- HEK-293 Cells
- Purification/Conjugué
- Cette C5 protéine est marqué à la His tag.
- Attributs du produit
- Mouse Complement C5 Protein, His Tag
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product C5 Protéine
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -20 °C
-
- Antigène
- C5 (Complement Component 5 (C5))
- Autre désignation
- Complement C5 (C5 Produits)
- Synonymes
- C5 Protein, LOC565774 Protein, C5a Protein, C5b Protein, CPAMD4 Protein, Hc Protein, RGD1561905 Protein, He Protein, complement C5 Protein, complement component 5 Protein, hemolytic complement Protein, C5 Protein, c5 Protein, Hc Protein
- Sujet
- Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
- Poids moléculaire
- 73.5 kDa (β chain) & 114.6 kDa (α chain)
- Pathways
- Système du Complément, Carbohydrate Homeostasis
-