Notch1 Protein (AA 19-526) (Fc Tag)
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- Antigène Voir toutes Notch1 (NOTCH1) Protéines
- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 19-526
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Origine
- Humain
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Source
- HEK-293 Cells
- Purification/Conjugué
- Cette Notch1 protéine est marqué à la Fc Tag.
- Attributs du produit
- Human NOTCH1 Protein, Fc Tag (MALS verified)
- Pureté
- >95 % as determined by SDS-PAGE.
- niveau d'endotoxine
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product NOTCH1 Protéine
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Notch 1 (NOTCH1) (AA 19-526) protein (His-Avi Tag)
NOTCH1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Notch 1 (NOTCH1) protein (His-Avi Tag,Biotin)NOTCH1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Notch 1 (NOTCH1) protein (His tag)NOTCH1 Origine: Souris Hôte: Human Cells Recombinant > 95 % as determined by reducing SDS-PAGE.
Notch 1 (NOTCH1) (AA 2309-2555) protein (His tag)NOTCH1 Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses ELISA, WB
Notch 1 (NOTCH1) (Active) protein (His tag)NOTCH1 Origine: Souris Hôte: Baculovirus infected Insect Cells Recombinant > 82 % as determined by SDS-PAGE Active
Notch 1 (NOTCH1) (AA 23-132) protein (GST tag)NOTCH1 Origine: Humain Hôte: Wheat germ Recombinant ELISA, WB, AP, AA
Notch 1 (NOTCH1) (AA 19-526) (Active) protein (His tag)NOTCH1 Origine: Souris Hôte: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- Indications d'application
- MALS verified
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Stock
- -20 °C
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- Antigène
- Notch1 (NOTCH1) (Notch 1 (NOTCH1))
- Autre désignation
- NOTCH1 (NOTCH1 Produits)
- Synonymes
- notch1 Protein, NOTCH1 Protein, hn1 Protein, tan1 Protein, notch Protein, xotch Protein, xnotch Protein, notch-1 Protein, xnotch1 Protein, TAN1 Protein, hN1 Protein, 9930111A19Rik Protein, Mis6 Protein, N1 Protein, Tan1 Protein, lin-12 Protein, NOTCH Protein, Xotch Protein, notch1-a Protein, notch 1 Protein, fibropellin-1 Protein, Notch homolog 1, translocation-associated (Drosophila) Protein, Notch homolog 1, translocation-associated Protein, notch 1 S homeolog Protein, notch1 Protein, LOC100631526 Protein, NOTCH1 Protein, Notch1 Protein, notch1.S Protein
- Sujet
- NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1. The NOTCH1 intracellular domain interacts with SNW1, the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ. The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
- Poids moléculaire
- 80.0 kDa
- Pathways
- Signalisation Notch, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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