IL-21 Protein (AA 30-162)

N° du produit ABIN7199412

Détail du produit

Antigène: IL-21 (IL21) (Interleukin 21 (IL21))

Type de proteíne: Recombinant

Activité biologique: Active

Attributs du protein: AA 30-162

Origine: Humain

Source: HEK-293 Cells

Fonction: Human IL-21 Protein, Tag Free, low endotoxin (HPLC verified)

Pureté: >98 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 0.01 EU per μg by the LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: PBS, pH 7.4

Stock: -20 °C

Détail du antigène

Antigène: IL-21 (IL21) (Interleukin 21 (IL21))

Autre désignation: IL-21 (IL21 Produits)

Synonymes: IL-21 Protein, Za11 Protein, interleukin 21 Protein, IL21 Protein, Il21 Protein

Sujet: Interleukin-21 (IL-21) is a secreted protein which belongs to the IL-15 / IL-21 family. Interleukin-21 / IL-21 belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor (IL21R) and the common cytokine receptor gamma chain (gamma(C)). Interleukin-21 / IL-21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. The IL-21R is widely distributed on lympho-haematopoietic cells. IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.

Poids moléculaire: 15.5 kDa

NCBI Accession: NP_068575

Pathways: Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response