DR3/LARD Protein (AA 25-199) (Fc Tag)

N° du produit ABIN7092807

Détail du produit

Antigène: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Type de proteíne: Recombinant

Attributs du protein: AA 25-199

Origine: Humain

Source: HEK-293 Cells

Purification/Conjugué: Cette DR3/LARD protéine est marqué à la Fc Tag.

Fonction: Recombinant Human TNFRSF25 with C-terminal human Fc tag

Specificité: TNFRSF25 (Gln25-Gln199) hFc (Glu99-Ala330)

Attributs du produit: Extracellular Domain Protein

Purification: Purified from cell culture supernatant by affinity chromatography

Pureté: The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.

Stock: -20 °C,-80 °C

Stockage commentaire: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Date de péremption: 12 months

Détail du antigène

Antigène: DR3/LARD (TNFRSF25) (Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25))

Autre désignation: TNFRSF25 (TNFRSF25 Produits)

Synonymes: APO-3 Protein, DDR3 Protein, DR3 Protein, LARD Protein, TNFRSF12 Protein, TR3 Protein, TRAMP Protein, WSL-1 Protein, WSL-LR Protein, Tnfrsf12 Protein, Wsl Protein, TNFRSF25 Protein, TNF receptor superfamily member 25 Protein, tumor necrosis factor receptor superfamily, member 25 Protein, TNFRSF25 Protein, Tnfrsf25 Protein

Sujet: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

Poids moléculaire: predicted molecular mass of 45.0 kDa after removal of the signal peptide. The apparent molecular mass of TNFRSF25-hFc is 55-70 kDa due to glycosylation.

UniProt: Q93038

Pathways: Apoptose