Claudin 18.2 protein-VLP

N° du produit ABIN7199152

Détail du produit

Antigène: Claudin 18.2

Type de proteíne: VLP

Origine: Humain

Source: HEK-293 Cells

Fonction: Human Claudin-18.2 Full Length Protein-VLP (HEK293)

Séquence: Met 1 - Val 261

Attributs du produit: Human Claudin-18.2 Full Length Protein-VLP (CL2-H52P7) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Val 261 (Accession # P56856-2 ).

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Information d'application

Indications d'application: The protein has a calculated MW of 27.7 kDa.

Commentaires:

Virus-like particles (VLPs) are formed by self-assembly of envelop/capsid proteins from viruses. Membrance Proteins can be constituted in-situ with VLPs produced from HEK293 cell cultures. These VLPs concentrate conformationally intact membrane proteins directly on the cell surface and produce soluble, high-concentration proteins perfect for immunization and antibody screening.
The VLPs provide the display of properly folded membrane proteins in their native cellular membrane in a compact size of 100~300 nm diameter (similar to the size of most viruses) making it optimal targets for dendritic cells in vivo and surface attachment for phage display.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS, pH 7.4

Stock: -80 °C

Stockage commentaire: -70°C

Détail du antigène

Antigène: Claudin 18.2

Autre désignation: Claudin-18.2

Sujet: Synonyms: Claudin-18.2,CLDN18,Claudin-18,
Description: Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14,15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.

Poids moléculaire: 27.7 kDa

NCBI Accession: NP_001002026