TLR3 Protein (Fc Tag)

N° du produit ABIN7121466

Détail du produit

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Type de proteíne: Recombinant

Origine: Souris

Source: HEK-293 Cells

Purification/Conjugué: Cette TLR3 protéine est marqué à la Fc Tag.

Fonction: Mouse TLR3 / CD283 Protein, Fc Tag (MALS verified)

Séquence: Thr 26 - Leu 705

Attributs du produit: Human TLR3, Fc Tag (TL3-M5255) is expressed from human 293 cells (HEK293). It contains AA Thr 26 - Leu 705 (Accession # Q99MB1-1).

Pureté: >95 % as determined by SDS-PAGE.

niveau d'endotoxine: Less than 1.0 EU per μg by the LAL method.

Classe de qualité: MALS verified

Information d'application

Indications d'application: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 103.7 kDa. The protein migrates as kDa under reducing (R) condition due to glycosylation.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH 7.5

Stock: -20 °C

Stockage commentaire: -20°C

Détail du antigène

Antigène: TLR3 (Toll-Like Receptor 3 (TLR3))

Autre désignation: TLR3 / CD283 (TLR3 Produits)

Synonymes: CD283 Protein, IIAE2 Protein, AI957183 Protein, zgc:123006 Protein, toll like receptor 3 Protein, toll-like receptor 3 Protein, TLR3 Protein, Tlr3 Protein, tlr3 Protein

Sujet: Synonyms: TLR3,CD283,IIAE2,
Description: Toll-like receptor 3 (TLR3) is also known as CD283, which belongs to the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 / CD283 contains 22 LRR (leucine-rich) repeats, 1 LRRCT domain, 1 LRRNT domain and 1 TIR domain. TLR3 is expressed at high level in placenta and pancreas and also detected in CD11c+ immature dendritic cells. CD283 / TLR3 is only expressed in dendritic cells. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons. CD283 / TLR-3 is the key component of innate and adaptive immunity. TLR3 / CD283 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. TLR3 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Defects in TL-R3 are associated with herpes simplex encephalitis type 2 (HSE2).

Poids moléculaire: 103.7 kDa

NCBI Accession: NP_569054

Pathways: Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades